Waddington, Dynamic Systems, and Epigenetics
نویسندگان
چکیده
منابع مشابه
Waddington, Dynamic Systems, and Epigenetics
Waddington coined the term "epigenetic" to attempt to explain the complex, dynamic interactions between the developmental environment and the genome that led to the production of phenotype. Waddington's thoughts on the importance of both adaptability and canalization of phenotypic development are worth recalling as well, as they emphasize the available range for epigenetic action and the import...
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Epigenetics is most often reduced to chromatin marking in the current literature, whereas this notion was initially defined in a more general context. This restricted view ignores that epigenetic memories are in fact more robustly ensured in living systems by steady-state mechanisms with permanent molecule renewal. This misconception is likely to result from misleading intuitions and insufficie...
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Denis Noble discusses Conrad Waddington's classic paper, "The genetic assimilation of the bithorax phenotype", published in Evolution in 1956.
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Stress plays a substantial role in shaping behavior and brain function, often with lasting effects. How these lasting effects occur in the context of a fixed postmitotic neuronal genome has been an enduring question for the field. Synaptic plasticity and neurogenesis have provided some of the answers to this question, and more recently epigenetic mechanisms have come to the fore. The exploratio...
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ژورنال
عنوان ژورنال: Frontiers in Behavioral Neuroscience
سال: 2016
ISSN: 1662-5153
DOI: 10.3389/fnbeh.2016.00107